Journal article
Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle
KE Boyle, H Hwang, RC Janssen, JM DeVente, LA Barbour, TL Hernandez, LJ Mandarino, M Lappas, JE Friedman
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
The rising prevalence of gestational diabetes mellitus (GDM) affects up to 18% of pregnant women with immediate and long-term metabolic consequences for both mother and infant. Abnormal glucose uptake and lipid oxidation are hallmark features of GDM prompting us to use an exploratory proteomics approach to investigate the cellular mechanisms underlying differences in skeletal muscle metabolism between obese pregnant women with GDM (OGDM) and obese pregnant women with normal glucose tolerance (ONGT). Functional validation was performed in a second cohort of obese OGDM and ONGT pregnant women. Quantitative proteomic analysis in rectus abdominus skeletal muscle tissue collected at delivery reve..
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Grants
Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
This research was supported by grants from the National Institutes of Health 5R01 DK062155 (J.E.F.), Colorado Nutrition Obesity Research Center, P30 DK048520 (J.E.F.), and R01 DK078645 (L.A.B.) [http://www.nih.gov], and from the Medical Research Foundation for Women and Babies; (M.L.) [http://www.mrfwb.org.au] and the Diabetes Australia Research Trust; (M.L.) [http://www.diabetesaustralia.com.au]. M.L. was supported by a Career Development Fellowship from the National Health and Medical Research Council, grant no. 1047025 [https://www.nhmrc.gov.au]. K.E.B. was supported by the National Institutes of Health F32 DK089743 and K12 HD057022 [http://www.nih.gov]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.